Recently, the national center for food safety risk assessment from Beijing, China, the researchers said the researchers from stevia sugar found more nutrients except stevia sugar, including the glycosidic diterpene, chlorogenic acid, flavonoid, vitamin, etc.
However, recent studies have shown that stevia extract has stronger antioxidant properties and anti-proliferation effects than diterpene glycosides in tumor cells.
To assess the toxicity of stevia, the researchers conducted extensive experiments in vitro and in vivo.The negative toxicity of a bacterial reverse mutation analysis, mouse bone marrow micronuclear test and sperm deformities in mice was recorded.The study showed that in 90 days, the oral concentration of stevia extract was 1.04%, 2.08% and 3.12%, which did not cause behavioral, hematological, clinical or histopathological changes in rats.In addition, in the study of 90 days, did not find dead or treatment related in the bad performance, between the experimental group and the control group, there is no weekly food intake and body weight of rats was observed significant differences.
The results showed that the rats' cholesterol, protein and albumin were significantly reduced.
Toxicity studies of stevia extract showed that neither genotoxicity nor chronic oral toxicity was 300 times the recommended daily intake.The scientific data prove the safety of the bioactive ingredient of stevia, so it can act as a functional active ingredient in functional foods and nutritional supplements.